Multiple System Atrophy (MSA) Treatment with Stem Cells

Living with MSA can be a challenge on all levels, from the loss of being able to walk or even a problem in speaking to weaker bodily functions. You are not alone in this journey. Learning about MSA and new treatments, such as stem cell therapy, may minimize symptoms. In this article, we break down what MSA is, how stem cell treatment for multiple system atrophy could help, and what one can expect from multiple system atrophy alternative treatments so you could feel more in control.

Understanding Multiple System Atrophy (MSA)

MSA affects about 5 out of every 100000 people. Estimates range from 1.9 to 4.9 out of 100000 people, depending on the population. Let’s look deeper into this disease.

What Is MSA?

MSA is an extremely rare, progressive neurodegenerative disease of both the central and autonomic nervous systems. Two types of MSA: 

• MSA-P, mainly mimicking Parkinson’s;
• MSA-C, also marked by lack of coordination and balance.

Symptoms typically begin in mid-adulthood, and the disease progresses rapidly to cause profound disability in daily life. There is currently no cure, and the latest treatments for MSA are focused on symptom management to improve comfort and functionality.

Symptoms and Stages of MSA

MSA can present with many varied symptoms, and these also vary greatly between individual cases:

Motor symptoms:

• Muscle rigidity, slowness of movement, and tremors;
• Difficulty maintaining balance and coordination, with an unsteady gait;

Autonomic dysfunction:

• A severe drop in blood pressure resulting in dizziness or fainting;
• Urinary urgency or incontinence;
• Impotence in men and a decreased libido in women;

Other symptoms:

• Sleep disturbances, REM sleep behavior disorder;
• Slurred speech;
• Memory disturbances.

MSA often passes through a number of phases:

• Early stage: The patients may be slightly imbalanced or have a slight tremor
• Middle stage: The difficulty with movement and balance. The autonomic symptoms of patient can be severe and be the disabilities of daily living
• Late stage: Patients may be confined to a wheelchair or need assistance to attend to activities of daily living. The progression leads to the inability to breathe or swallow, requiring ventilation and tube feeding. The disease is fatal, with patients typically wheelchair-bound within 5–6 years and an average life expectancy of 10–11 years.

Traditional Treatment Approaches and Their Limitations

Management in MSA is primarily symptomatic; hence, the main objective of medications use and multiple system atrophy alternative treatments is alleviation of symptoms to improve the quality of life in patients.

Symptomatic management

Pharmacological therapy is a standard treatment. Only about a third have a good response that tends to wane over time. One of the side effects is blood pressure drop.

Management of orthostatic hypotension

Midodrine and droxidopa can be used to manage low blood pressure on standing. Common side effects include supine hypertension and other cardiovascular complications.

Management of autonomic dysfunction

Associated autonomic symptoms, like bladder dysfunction, are treated with anticholinergic drugs or by catheterization. Among side effects are urinary retention or the risk of infections.

Physiotherapy

Physiotherapy may improve mobility and balance; however, its effectiveness can vary greatly between patients.

Limitations of current treatments

• None of the treatments currently available modify the course of MSA or stop its progression.
• Unfortunately, many patients poorly respond to the conventional treatments of diseases. This makes them frustrated and results in inadequate symptomatic medication.
• Medications usually have substantial side effects that seem to alter life quality.

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Dr. Aleksandra Fetyukhina, MD

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Introduction to Stem Cell Therapy for MSA

Stem cell treatment for multiple system atrophy may facilitate the repair mechanisms of the body, slowing down the disease progression and improving the quality of life of patients.

How Stem Cell Therapy Works for Neurological Conditions

Treating multiple system atrophy with stem cell therapy helps ease this condition by various means. 

Neuroprotection

The neuroprotective factors secreted by MSCs of the body are like BDNF and GDNF, encourage the promotion of neuron survival, reduction of cell death, and support of healthy brain cells. 

Immunomodulation

Managing multiple system atrophy with stem cell treatment helps regulate immune responses by reducing inflammation-causing cells and boosting anti-inflammatory factors. MSCs help create a better environment for brain repair and slow further neurological damage.

Stimulation of brain repair 

Stimulation of brain repair through the secretion of trophic signals helps improve brain connectivity and function.

Angiogenesis

Managing MSA stem cell treatment can stimulate blood vessel growth in the damaged areas of the brain, improving the blood and nutrient supply. This is important for recovery and health of the brain.

The Science Behind Stem Cells and MSA Treatment

Randomized clinical trial in patients with MSA-C has shown an improvement in neurological deficits in those receiving autologous MSC therapy, compared to the control placebo group, during a year follow-up. This suggests that treating multiple system atrophy with stem cell therapy may help delay symptom progressions of MSA.

Success Stories: Real-World Examples of MSA Patients

Steve’s story gives hope in multiple system atrophy with stem cell therapy. He had undergone a clinical trial with the use of adult stem cells from his fat tissues. Steve noticed that his treatment helped delay the progression of his symptoms and returned to an active lifestyle, which was impossible before the stem cell treatment for multiple system atrophy.

Advantages of Stem Cell Therapy for Multiple System Atrophy

These are promising advantages that treatment with stem cell transplants for MSA  holds for patients.

Slowing of Disease Progression

MSA treatment with stem cells helps preserve neuronal function and therefore gradually reduce the deterioration in motor and cognitive abilities, which may be the cause of delayed loss of independence and life quality.

Motor and Autonomic Function

Patients treating multiple system atrophy with stem cell therapy also show distinctive improvements in motor functions such as mobility and coordination, and also in regulating blood pressure and bladder control. This helps decrease dependency on supporting devices.

Improved Quality of Life

Managing MSA with stem cell treatment increases energy, enhances mood, and promotes better social interaction. It can reduce debilitating symptoms and help patients regain their independence to improve overall well-being.

How Do I Choose a Reliable Clinic for Stem Cell Therapy for MSA?

You might be asking yourself, “Where can I get stem cell therapy for MSA?” Choosing a clinic with proven expertise is key for effective treatment. Swiss Medica stands out for its expertise in advanced stem cell therapy, offering personalized programs designed to support each patient’s unique journey toward improvement.

• We schedule a no-obligation online consultation with our experts to discuss your options for stem cell treatment for multiple system atrophy.
• Our MSA stem cell therapy all-inclusive package includes: preparation before treatment, main therapy, comfortable accommodation, support after treatment, and alternative therapies for MSA like physiotherapy.
• We have a favorable doctor-to-patient ratio, hence individual care for every patient.
• Patients in our hotel-type clinic stay under comfortable conditions, according to their preferences in the menu, in a quiet and friendly atmosphere.  

Swiss Medica now operates two clinics, one in Serbia and one in Slovenia, alongside a state-of-the-art five-building hospital in Belgrade, Serbia. This expansion allows the clinic to provide a broader range of services to patients. Our convenient location makes it easy for international patients seeking advanced MSA stem cell therapy to access our care.

The Stem Cell Treatment Process for MSA: What to Expect

1. Before starting stem cell treatment for multiple system atrophy, patients have a thorough consultation with our doctor. This includes reviewing symptoms, medical history, and conducting neurological tests to assess neuronal damage.
2. Stem cells used for MSA treatment can come from various sources. There may be bone marrow stem cell transplants for MSA, stem cells from adipose tissue and umbilical cord blood, or neural stem cells. These cells are processed and prepared in our in-house lab, where strict quality control measures ensure their safety and viability for treatment.
3. After preparation, our doctors deliver stem cells through intrathecal injection (into the spinal canal) or intravenous infusion, depending on the patient’s needs. Any immediate side effects are carefully monitored.
4. Follow-up visits track progress of MSA treatment with stem cells through clinical exams and imaging. Our patients usually notice symptom improvements after several weeks or months.

Safety and Complications of Stem Cell Treatment for MSA

The patients may feel a few minor side effects after the administration of the stem cell treatment: 

• Reactions at the injection sites; 
• Fever;
• Fatigue.

Swiss Medica maintains all the safety measures in order to avoid all the risk factors during treatment with stem cell transplants for MSA on all levels:

• We assess the case history of each patient in detail to decide whether or not stem cell therapy is appropriate.
• Stem cells are extracted from donors in sterile, germ-free environments to avoid contamination.
• Quality and viability check at each level of processing are the checkpoints for stem cells.

Cost of Stem Cell Therapy for MSA and Insurance Information

The cost of stem cell transplants for MSA can vary greatly depending on the geographical region, type of stem cells, and treatment protocol. In the United States, costs typically range from $20000 to $35000 per session, though more affordable options that do not compromise on quality exist in countries like Serbia. The Swiss Medica stem cell treatment for multiple system atrophy costs between €7,000 to €31,000*, based on the treatment program and additional procedures. Because the overwhelming majority of insurance plans do not currently cover stem cell therapy for multiple system atrophy, patients usually pay out-of-pocket.

*The prices mentioned are indicative and subject to change based on individual factors, including the condition’s severity and the number of stem cells needed. Prices are valid as of January 2025.

Comparing Stem Cell Therapy with Other MSA Treatments

Medications vs. Stem Cells: Which Offers Better Results?

Traditional drugs like levodopa and dopamine agonists help reduce symptoms of MSA but do little to slow disease progression. In contrast, stem cell therapy, especially MSCs, may not only manage symptoms but also slow down the disease’s progress.

Combining Therapies for Maximum Effectiveness

Combining stem cell treatment for multiple system atrophy with immunotherapy, anti-inflammatory treatments, or deep brain stimulation (DBS) could lead to better motor function and improved quality of life.

Lifestyle Changes and Rehabilitation as Complementary Approaches

Additionally, doctors may recommend multiple system atrophy alternative treatments like physical therapy, occupational therapy, and regular exercise to maintain mobility, build strength, and improve overall health. Proper nutrition can help manage symptoms and support recovery after treatment.

Future of Stem Cell Therapy for Multiple System Atrophy

Latest Research and Clinical Trials

Recent studies show promise for stem cell transplants for MSA. One trial with autologous MSCs showed slower neurological decline compared to a placebo. Another study using intrathecal mesenchymal stem cell therapy in multiple system atrophy found that higher doses helped delay disease progression, suggesting stem cell therapy could be effective for MSA.

Innovations in Stem Cell Treatment Technologies

Advances in stem cell technology have made the latest treatment for MSA much safer and more effective. Improved methods now allow for better stem cell isolation, expansion, and delivery—especially with intrathecal injections that directly target the central nervous system for more precise stem cell treatment for multiple system atrophy.

What the Future Holds for MSA Patients

The latest treatments for MSA offers hope with ongoing research focused on making protocols more effective and expanding its clinical use. Each new trial brings us closer to establishing stem cell therapy as a treatment that could slow disease progression and improve quality of life. Advances in personalized medicine also mean treatments can be tailored to each patient, helping them receive the most effective care. 

Frequently Asked Questions About Multiple System Atrophy Stem Cell Cure

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Contact us to learn about the expected results of the treatment, its cost and duration.

Dr. Aleksandra Fetyukhina, MD

Medical Advisor, Swiss Medica doctor

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Alex Hitch Author

Dr. Lana Reviewer

MD, Pediatrician, Regenerative Medicine Specialist